ABSTRACT
Background: Sudden exacerbations and respiratory failure are major causes of death in patients with severe coronavirus disease 2019(COVID-19) pneumonia, but indicators for the prediction and treatment of severe patients are still lacking.MethodsA retrospective analysis of 67 collected cases was conducted and included approximately 67 patients with COVID-19 pneumonia who were admitted to the Suzhou Fifth People’s Hospital from January 1, 2020 to February 8, 2020. The epidemiological, clinical and imaging characteristics as well as laboratory data of the 67 patients were analyzed.ResultsThe study found that fibrinogen(FIB) was increased in 45 (65.2%) patients, and when FIB reached a critical value of 4.805 g/L, the sensitivity and specificity、DA, helping to distinguish general and severe cases, were 100% and 14%、92.9%, respectively, which were significantly better than those for lymphocyte count and myoglobin. Chest CT images indicated that the cumulative number of lung lobes with lesions in severe patients was significantly higher than that in general patients (P<0.05), and the cumulative number of lung lobes with lesions was negatively correlated with lymphocyte count and positively correlated with myoglobin and FIB. Our study also found that there was no obvious effect of hormone therapy in patients with severe COVID-19.ConclusionsBased on the retrospective analysis, FIB was found to be increased in severe patients and was better than lymphocyte count and myoglobin in distinguishing general and severe patients. The study also suggested that hormone treatment has no significant effect on COVID-19.
Subject(s)
Coronavirus Infections , Pneumonia , Disease Progression , Erythema Infectiosum , COVID-19 , Respiratory InsufficiencyABSTRACT
Background Sudden exacerbations and respiratory failure are major causes for the death of severe COVID-19 pneumonia patient and but now the detection and treatment of severe patients is still lack. Methods A retrospective analysis is conducted on 69 collected cases, which are about 69 patients with COVID-19 pneumonia who were admitted to the Suzhou Fifth People’s Hospital from January 1, 2020 to February 8, 2020. Their epidemiological, clinical and imaging characteristics as well as laboratory data of the 69 patients were analyzed. Results The study found fibrinogen increased in 45 (65.2%) patients and when the fibrinogen takes a critical value of 4.805 g/L, the sensitivity and specificity, helping distinguish general and severe classification, are 100% and 14%, respectively, which are significantly better than lymphocyte and myoglobin. Chest CT images indicate that the cumulative number of lung lobes in severe patients were significantly higher than that in general patients (P＜0.05) and the cumulative number of lung lobes in the lesions was negatively correlated with lymphocyte, and positively correlated with myoglobin and fibrinogen. Our study also found that there is no obvious effect of hormone therapy in severe patients with COVID-19. Conclusions Based on the retrospective analysis, the fibrinogen were found increased in severe patients and were better than lymphocyte and myoglobin in respect of distinguishing general and severe patients. And the study also suggested hormone treatment has no significant effect on COVID-19.